Which statement best describes erythema multiforme?

• A. Acute illness; hypersensitivity; drugs
• B. Round lesions on forearms, hands, knees or feet
• C. Lesions appear like a target with fluid filled blister in center
• D. Common, self-limiting

Answer: (C)

The key point being tested is the characteristic skin finding of erythema multiforme. This condition is a hypersensitivity reaction that most often shows target (iris) lesions—concentric rings with a central area that may blister or necrose. These target lesions are the hallmark, typically appearing on the distal extremities such as the forearms, hands, knees, and feet. While erythema multiforme can be triggered by infections (notably herpes simplex) or certain drugs and is often self-limiting, the defining clue for diagnosis in exam questions is the presence of target lesions with a fluid-filled center. The other statements may describe potential triggers or general aspects, but they do not capture the distinctive lesion morphology as clearly.