Discoid lupus erythematosus is associated with deposition of which immunoglobulins in the skin?

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Multiple Choice

Discoid lupus erythematosus is associated with deposition of which immunoglobulins in the skin?

Explanation:
Discoid lupus erythematosus shows immune complex deposition at the dermal-epidermal junction. In lesional skin, direct immunofluorescence often reveals a lupus band: granular deposits of immunoglobulins and complement along the basement membrane, most commonly IgG and IgM with C3. This reflects immune complexes formed by autoantibodies to nuclear antigens in the skin, driving inflammation and the typical scarring plaques. IgA, IgE, or IgD are not the usual players in this pattern, making IgG and IgM the best fit.

Discoid lupus erythematosus shows immune complex deposition at the dermal-epidermal junction. In lesional skin, direct immunofluorescence often reveals a lupus band: granular deposits of immunoglobulins and complement along the basement membrane, most commonly IgG and IgM with C3. This reflects immune complexes formed by autoantibodies to nuclear antigens in the skin, driving inflammation and the typical scarring plaques. IgA, IgE, or IgD are not the usual players in this pattern, making IgG and IgM the best fit.

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